Jamie is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman—a radical spirit named Crystal Fairy—to come along.
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When the great potato famine hits Ireland, the diaspora begins as thousands emigrate. Among those leaving the Emerald Isle is Katie O’Neill and her husband, who decide that the promised land is South Africa and make their way there. Once there, they discover the hardships that are the reality of the homesteader experience.