Jack Thornton has trouble winning enough at cards for the stake he needs to get to the Alaska gold fields. His luck changes when he pays $250 for Buck, a sled dog that is part wolf to keep him from being shot by an arrogant Englishman also headed for the Yukon. En route to the Yukon with Shorty Houlihan — who spent time in jail for opening someone else’s letter with a map of where gold is to be found — Jack rescues a woman whose husband was the addressee of that letter. Buck helps Jack win a $1,000 bet to get the supplies he needs. And when Jack and Claire Blake pet Buck one night, fingers touch.
American chemist Ned Faraday marries a German entertainer and starts a family. However, he becomes poisoned with Radium and needs an expensive treatment in Germany to have any chance at being cured. Wife Helen returns to night club work to attempt to raise the money and becomes popular as the Blonde Venus. In an effort to get enough money sooner, she prostitutes herself to millionaire Nick Townsend.