A glowing brain-like creature arrives on a beach near a rocket test site via a teleportation beam. The alien communicates telepathically with the children of scientists. The kids start doing the alien’s bidding as the adults try to find out what’s happening to their unruly offspring.
Buffalo Bill and Wild Bill Hickok join forces to establish a mail route that can get mail from St. Joseph, Missouri, to Sacramento, California, in ten days. Along the way they must battle bad weather, hostile Indians and outlaws intent on robbing the mail and shutting down the entire operation.