Picking up directly where the previous film left off, the story follows Riley, one of the last people to come in contact with Samantha, as he scrambles to track down those responsible for the outbreak before the highly contagious disease not only consumes his body, but the world as we know it.
A fidgety, wisecracking video store clerk develops a fixation on a particularly reclusive customer, a frequent visitor to the pornography section of Cinefile, the video store where he works in Los Angeles. After multiple failures to impress her during their brief daily transactions, he finds her street address in the store’s database, drives to her apartment building and initiates an unconventional campaign to win her affections.
The provocative tale of a woman who snaps under crushing life pressures and assumes the psyche of a vicious dog. Her philandering, absentee husband is forced to become reacquainted with his four children and sister-in-law as they attempt to keep the family together during this bizarre crisis.